GW9662:原理_价格_参数_使用方法-耗材谱::分析测试百科网

溶解性	Soluble in DMSO (26 mg/ml), methanol, 100% ethanol (10 mg/ml), DMF (~35 mg/ml), and 1:2 DMF : PBS (PH=7.2) (~0.5 mg/ml). Insoluble in water.
存贮条件	储存温度2-8°C

应用	A selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist.
产品介绍	GW9662是一种选择性PPAR拮抗剂，作用于PPARγ，IC50为3.3 nM，作用于PPARγ比作用于PPARα和PPARδ选择性强100到1000倍。
备注	GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγversus PPARα and PPARδ.
生化机理	GW 9662 is a selective, irreversible, and effective peroxisome proliferator activated receptor-γ (PPARγ) antagonist. PPARγ research demonstrates that GW 9662 covalently modifies Cys(285) and does not affect transcription of full-length PPARα and PPARδ. GW 9662 has been shown to block Rosiglitazone mediated activation of PPARγ, and improve growth inhibition induced by Rosiglitazone in breast tumor cell research. Additionally, reports indicate that GW 9662 blocks the protective activity of lipopolysaccharide, LPS, and acts as an agonist for the farnesoid X receptor (FXR) and pregnane X receptor (PXR) nuclear receptors.
别名	2-氯-5-硝基苯甲酰苯胺;2-氯-5-硝基-N-苯基苯酰胺;GW 9662;GW-9662;2-Chloro-5-nitro-N-phenylbenzamide

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