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产品描述
| 溶解性 | Soluble in water (26 mg/ml), ethanol (207 mg/ml), methanol (> 40%), DMF (~14 mg/ml), and DMSO (72 mg/ml at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An antiproliferative 5-fluorouracil releasing compound |
| 产品介绍 | Capecitabine是一种治疗肿瘤选择性的氟嘧啶氨基甲酸酯，具有较高的瘤内5-FU水平，且毒性比5-FU低。 |
| 备注 | Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. |
| 生化机理 | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil. From Wikipedia. |
| 别名 | 卡培他滨;5'-脱氧-5-氟-N4-[(戊氧基)羰基]胞啶;Ro-9-1978;5′-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine;5'-Deoxy-5-fluoro-N4-[((pentyloxy)carbonyl]cytidine |
