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产品描述
| 溶解性 | DMSO ≥45mg/mL Water <1.2mg/mL Ethanol <1.2.mg/mL |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | A potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents |
| 产品介绍 | Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition. |
| 备注 | Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. It is inactive to SIRT2. Phase 1/2. |
| 生化机理 | Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively. |
| 别名 | ABT-888;PARP抑制剂;ABT-888; 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide |
