UPF 1069:原理_价格_参数_使用方法-耗材谱::分析测试百科网

沸点	~570.3 °C at 760 mmHg
熔点	166-168 °C
折光率	1.62
溶解性	DMSO 56 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C
密度	1.3000

应用	A selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor.
产品介绍	UPF 1069是PARP2选择性抑制剂，IC50为0.3 μM，比对PARP1的抑制性高27倍。
生化机理	In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury.
别名	UPF-1069; UPF1069;5-(2-氧代-2-苯基乙氧基)-1(2H)-异喹啉酮;UPF-1069; UPF1069;5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone

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