Scriptaid:原理_价格_参数_使用方法-耗材谱::分析测试百科网

溶解性	DMSO 65 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

备注	Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.
生化机理	A novel HDAC inhibitor, Scriptaid, has been found to have robust activity and lower toxicity compared to trichostatin A (TSA). Although Scriptaid induced activation of both p38MAPK and JNK, it was the inhibition of JNK that attenuated Scriptaid-induced apoptosis significantly. Scriptaid also increased the expression of (i) p21 and p27 involved in cell-cycle regulation and (ii) γH2AX associated with DNA damage response in a JNK-dependent manner.
别名	Scriptide, GCK 1026;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-;Scriptide, GCK 1026;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-

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