Mizoribine:原理_价格_参数_使用方法-耗材谱::分析测试百科网

敏感性	对热敏感
溶解性	Soluble in water (52 mg/ml), DMSO (52 mg/ml), ethanol (<1 mg/ml), and methanol
存贮条件	储存温度 2-8°C

应用	An imidazole nucleoside immunosuppressant agent.
产品介绍	Mizoribine 是一种咪唑核苷，是一种免疫抑制剂，IC50约为100μM
备注	Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM.
生化机理	Mizoribine is an imidazole nucleoside immunosuppressant agent that was first isolated from the mold Eupenicillium brefeldimium with antibiotic and cytotoxic effects. In a mouse model for IgA nephropathy, Mizoribine was documented to influence the proliferation of B cells and decrease the glomerular IgA load while increasing glomerular expansion. In addition in human B cells the compound has been observed to Inhibit the expression of cyclin A. The immunosuppressive effects of Mizoribine Hydrobromide also effects T cells through suppression of G to S phase transition. In the case of puromycin aminonucleoside nephropathy Mizoribine demonstrated the ability to prevent podocyte injury. The compound has also been documented to induce the differentiation of promyelocytes on a mechansim relying on impaired guanine nucleotide synthesis.
别名	1-(β-D-呋喃核糖)-5-羟基咪唑-4-甲酰胺;咪唑立宾;1-(β-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide;N′-(β-D-Ribofuranosyl)-5-hydroxy-imida-zole-4-carboxamide;Bredinin; NSC 289637; (beta)-Bredinin; HE 69

标识符号	GHS07, GHS08
信号词	Danger
危害声明	H315-H319-H335-H360
警示性声明	P201-P261-P305 + P351 + P338-P308 + P313
个人防护设备	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS	NI3980000
WGK德国	3

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