产品描述
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in water (partly), DMF (~30 mg/ml), ethanol (50 mg/ml), methanol, and DMSO (86 mg/ml at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A progesterone and glucocorticoid antagonist, suppresses VEGF production. |
| 产品介绍 | Mifepristone是一种异常活跃的孕激素受体和糖皮质激素受体拮抗剂，IC50分别为0.2nM和2.6 nM。 |
| 备注 | Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. |
| 生化机理 | Mifepristone is a progesterone (PR) and glucocorticoid receptor (GR) antagonist which has demonstrated the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. It is also an inhibitor of the progesterone receptor. Mifepristone has been found to decrease basal bcl-2 messenger RNA levels in CA1 neural regions and the dentate gyrus. Experiments have shown that mifepristone potentially exhibits an inhibitory effect on embryo implantation via regulation of FAS and FAS-L apoptosis gene expression. Additionally, mifepristone displays anti-angiogenic characteristics via suppression of vascular endothelial growth factor (VEGF) production. Mifepristone may also prevent intracellular peroxide accumulation and cell death induced by hydrogen peroxide, glutamate, β-amyloid protein, or neurotoxins that have been associated with certain neurodegenerative disorders. |
| 别名 | RU-486;米非司酮;(1Lβ,17β)-11-[4-(二甲氨基)苯基]-17-羟基-17-(1-丙炔基)雌甾-4,9-二烯-3-酮;11β-[4-(N,N-二甲胺基)]苯基-17β-羟基-17α-(1-丙炔基)-雌甾-4,9-二烯-3-酮;RU-38486;RU-486;RU486;RU38486;11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one |
