产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | An HDAC6 inhibitor |
| 产品介绍 | Tubastatin A盐酸盐是HDAC6选择性抑制剂，IC50为15 nM，比对其它亚型的抑制性高1000倍（相对HDAC8是57倍）。 |
| 生化机理 | Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM. |
| 别名 | Tubastatin A 盐酸盐; N-羟基-4-[(1,2,3,4-四氢-2-甲基-5H-吡啶并[4,3-b]吲哚-5-基)甲基]苯甲酰胺盐酸盐;TSA HCl; Tubastatin A hydrochloride; N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride;N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride |
