溶解性 |
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存贮条件 | 储存温度-20°C |
应用 | A selective inhibitor of JAK2 tyrosine kinase |
产品介绍 | TG-101348 (SAR302503)是JAK2选择性抑制剂,IC50为3 nM,作用于JAK2比作用于JAK1和JAK3选择性高35和334倍,同时还能抑制BRD4,IC50为340 nM。 |
备注 | TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Phase 1/2. |
生化机理 |
TG-101348 is a potent, highly selective JAK2 inhibitor. |
别名 | TG101348; TG 101348;N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-[2-(1-吡咯烷基)乙氧基]苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺;Fedratinib;SAR 302503;N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide;N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide |