产品描述
| 溶解性 | DMSO 5 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A potent Raf-B inhibitor. |
| 产品介绍 | SB590885是一种有效的B-Raf抑制剂，Ki为0.16 nM，作用于B-Raf比作用于c-Raf选择性高11倍，对其他人类激酶没有抑制作用。 |
| 备注 | SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases. |
| 生化机理 | SB 590885 is known to be a potent Raf-B inhibitor. The compound has shown selectivity for Raf-B against 46 other kinases. SB 590885 has been shown to decreases anchorage-independent growth of melanoma cell lines and also known to inhibit phosphorylation and proliferation. |
| 别名 | 5-[2-[4-[2-(二甲基氨基)乙氧基]苯基]-5-(4-吡啶基)-1H-咪唑-4-基]-2,3-二氢-1-茚酮肟;SB-590885;SB-590885; SB 590885;5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime |
