产品描述
| 溶解性 | Soluble in DMF (~25 mg/ml), DMSO (96 mg/ml at 25 °C), ethanol (40 mg/ml at 25 °C), and methanol. Insoluble in water (25 oC). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An inhibitor of MEK and suppressor of ERK phosphorylation |
| 产品介绍 | PD0325901是一种选择性的，ATP非竞争性的MEK抑制剂，IC50为0.33 nM，对ERK1和ERK2磷酸化抑制作用比CI-1040强500倍左右 |
| 备注 | PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 1/2. |
| 生化机理 | PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK1/2 in murine colon 26 tumors with an IC50 value of 0.33 nM. As a result of this inhibition, PD 0325901 modulates regulators of cell growth and apoptosis at the protein level. Studies on M14 models indicate that PD 0325901 inhibits the phosphorylation of ERK and its downstream target ribosomal S6 kinase in a dose-dependent manner. This inhibition was rapid with complete, occurring at 15 minutes and lasting at least 72 hours. When combined with GSK-3 Inhibitor XVI (CHIR99021) this inhibitor prevents cell differentiation and sustains self renewal of murine embryonic stem cells for at least eight passages |
| 别名 | N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-[(2-氟-4-碘苯)氨基]苯甲酰胺;PD 0325901; PD-0325901;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide |
| 标识符号 |
GHS07
|
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| WGK德国 | 3 |
