产品描述
| 沸点 | 585.10 °C at 760 mmHg |
| 熔点 | 217.94 °C |
| 折光率 | 1.54 |
| 溶解性 |
|
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.4500 |
| 应用 | A potent and selective peroxisome proliferatior-activated recepter δ antagonist |
| 产品介绍 | GSK3787是不可逆的PPARδ选择性拮抗剂，pIC50为6.6，对hPPARα和hPPARγ无亲和力。 |
| 生化机理 |
GSK3787 is potent and selective PPAR beta/delta (Peroxisome Proliferator-Activated Receptor) antagonist (IC50 in PPAR ligand displacement assays = 200 nM against human PPARβ and >10 μM against PPARα or PPARγ). GSK3787 acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells. |
| 别名 | GSK 3787;GSK-3787；4-氯-N-(2-((5-(三氟甲基)-2-吡啶基)磺酰基)乙基)-苯甲酰胺;;GSK 3787;GSK-3787；4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide |
