敏感性 | 易吸湿 |
溶解性 | Soluble in water (30 mg/ml), DMSO (100 mM), methanol, and ethanol (25 mM). |
存贮条件 | 储存温度2-8℃ |
应用 | An inhibitor of HMGCR (HMG-CoA reductase). |
产品介绍 | Fluvastatin Sodium抑制HMG-CoA reductase(HMG-CoA还原酶)活性,IC50为8 nM。 |
备注 | Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM. |
生化机理 | Fluvastatin, Sodium Salt is a synthetic inhibitor of HMGCR (HMG-CoA reductase) (IC50 = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic compound and as an antioxidant. Fluvastatin also inhibits induction of the LDL receptor on HepG2 cells at a concentration of 0.1-1.0 μM. Research shows that fluvastatin can inhibit the formation of TBA-reactive substances in Fe(II)-supported peroxidation of liposomes (IC50 = 12 μM). |
别名 | 氟伐他汀钠; [R*,S*-(E)]-(+/-)-7-[3-(4-氟苯基)-1-(1-甲基乙基)-1-氢-吲哚-2-基]-3,5-二羟基庚-6-烯酸钠;Vastin;Leschol sodium;(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid monosodium salt |