产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Cobicistat (GS-9350)是一种有效的CYP3A选择性抑制剂，IC50为30 - 285 nM。 |
| 备注 | Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| 生化机理 |
Cobicistat is a drug under experimental investigation for use in the treatment of infection with the human immunodeficiency virus (HIV). Like ritonovir (Norvir), cobicistat is of interest not for its anti-HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. By combining cobicistat with elvitegravir, higher concentrations of elvitgravir are achieved in the body with lower dosing, theoretically enhancing elvitgravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only currently approved booster, cobicistat has no anti-HIV activity of its own…From Wikipedia. |
| 别名 | 可比司他;(3R,6R,9S)-12-甲基-13-[2-(1-甲基乙基)-4-噻唑基]-9-[2-(4-吗啉基)乙基]-8,11-二氧代-3,6-双(苯基甲基)-2,7,10,12-四氮杂十三烷酸 5-噻唑甲醇酯;GS-9350;GS 9350; GS9350;(3R,6R,9S)-12-Methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid 5-thiazolylmethyl ester |
