产品描述
| 沸点 | ~508.6° C at 760 mmHg |
| 熔点 | 128-134° C |
| 旋光率 | -58.0 to -62.0 deg(C=1, MeOH) |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
| 应用 | An antifungal CYP2C9 inhibitor |
| 产品介绍 | Voriconazole (伏立康唑; UK-109496) 是第二代三唑类抗真菌化合物，可作用于严重的真菌感染。 |
| 备注 | Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. |
| 生化机理 | Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes. Posaconazole is a highly potent broadspectrum antifungal drug. It blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase resulting in accumulation of methylated sterol precursors. In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole was able to produce a parasitological cure in a mouse model of the chronic stage of Chagas disease |
| 别名 | 伏立康唑; (2R,3S)-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇;Vfend;UK-109496; 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
