产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Varespladib (LY315920)是一种有效的，选择性的human non-pancreatic secretory phospholipase A2 (hnsPLA)（人类非胰腺分泌型磷脂酶A2）抑制剂，IC50为7 nM。 |
| 备注 | LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM,. Phase 3. |
| 生化机理 |
Varespladib (LY 315920), a specifically designed indolic secretory phospholipase A2 (sPLA2) inhibitor, has shown promising results in animals and adults. Inhibition seems to be inversely related to the severity of gas exchange impairment. Varespladib acts synergistically with pravastatin to decrease atherosclerosis, possibly through decreased levels of systemic inflammation or decreased lipid levels. Varespladib treatment also resulted in a profound increase in plasma PON activity and significantly larger fibrous caps, suggesting the formation of more stable plaque architecture. |
| 别名 | 伐瑞拉迪;LY-333013;[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid;LY 315920;LY315920;LY-315920 |
