溶解性 | Soluble in water (partly), DMSO (55 mg/ml at 25 °C), and water (55 mg/ml at 25 °C). |
存贮条件 | 储存温度 2-8°C |
应用 | An inhibitor of peripheral and central catechol-O-methyltransferase. |
产品介绍 | Tolcapone是一种有效和选择性的可逆硝基酚类儿茶酚-O-甲基转移酶(COMT)抑制剂,Ki为30nM。 |
备注 | Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM. |
生化机理 | Tolcapone is a orally active inhibitor of peripheral and COMT (central catechol-O-methyltransferase). Antiparkinsonian. |
别名 | 托卡朋; (3,4-二羟基-5-硝基苯基)-(4-甲基苯基)甲酮;Ro 40-7592; Tasmar;(3,4-Dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone |