产品描述
| 溶解性 | Soluble in chloroform, and DMSO. |
| 存贮条件 | 储存温度-20°C |
| 应用 |
A selective inhibitor of phosphodiesterase 4 罗氟司特已被用于评估其对小鼠熏烟法模型中急性肺部炎症和慢性肺部改变的影响。此外，它还可用于研究其在长期增效 (LTP)缓解原胚细胞诱发的缺陷方面的治疗潜力 |
| 产品介绍 | Roflumilast is a selective phosphodiesterase 4 (PDE4) (IC50 = 0.8 nM) inhibitor. Inhibition of PDE4 prevents the hydrolysis of phosphodiesters, which play a key role in signal transduction. This compound has anti-inflammatory properties and is particularly effective at reducing inflammation in lung tissue. |
| 备注 | Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM. |
| 生化机理 | 罗氟司特是一种高效、口服有效的选择性磷酸二酯酶4 (PDE4) 抑制剂，IC50 为 0.8 nM。罗氟司特具有抗炎作用，用于临床治疗COPD |
| 别名 | 罗氟司特,3-(环丙甲氧基)-N-(3,5-二氯吡啶-4-基)-4-(二氟甲氧基)苯甲酰胺;3-环丙基甲氧基-4-二氟甲氧基-N-[3,5-二氯-4-吡啶基]-苯甲酰胺;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide |
