产品描述
| 熔点 | 137°C |
| 溶解性 | Soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), chloroform, and methanol. |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A peripheral histamine H1 receptor agonist. |
| 产品介绍 | Loratadine是一种选择性的，逆向外周组胺H1受体激动剂，IC50大于32 μM。 |
| 备注 | Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. |
| 生化机理 | Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist (IC50 > 32 μM). |
| 别名 | 克敏能;氯雷他定;4-(8-氯-5,6-二氢-11H-苯并[5,6]环庚基[1,2-b]并吡啶-11-烯)-1-哌啶羧酸乙脂;4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester;Loratidine;SCH 29851; SCH29851; SCH-29851 |
