产品描述
| 溶解性 | DMSO 101 mg/mL (199.98 mM);Water 82 mg/mL (162.36 mM);Ethanol 101 mg/mL (199.98 mM) |
| 存贮条件 | 储存温度 2-8℃ |
| 应用 | A selective bradycardic agent. |
| 产品介绍 | Ivabradine HCl是一种新型If抑制剂，IC50为2.9 μM，特定有效作用于窦房结心脏起搏器活性，是一种纯粹的心跳速率降低剂。 |
| 备注 | Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. |
| 生化机理 | Ivabradine Hydrochloride, also known as S-16257, is the hydrochloride salt preparation of Ivabradine, a bradycardic agent. Studies have shown that Ivabradine inhibits T cell migration and causes a decrease of chemokine-induced PI-3 kinase activity. Exposure of rabbit sinoatrial node cells to Ivabradine has been reported to cause a blockade of the hyperpolarization-activated I(f) current without resulting in a shift of the voltage range of the activation curve. |
| 别名 | 盐酸伊伐布雷定;3-[3-[[(8S)-3,4-二甲氧基-8-双环[4.2.0]辛-1,3,5-三烯]甲基-甲氨基]丙基]-7,8-二甲氧基-2,5-二氢-1H-3-苯并氮杂卓-4-酮盐酸盐;Ivabradine hydrochloride;3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride |
