产品描述
| 溶解性 |
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| 存贮条件 | 储存温度 2-8°C |
| 应用 | A potent β2-AR agonist. |
| 产品介绍 | Formoterol Hemifumarate是一种有效的，选择性的，长效β2-肾上腺素受体激动剂，作用于β2和β1受体，pKd分别为8.12和5.58。 |
| 备注 | Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively. |
| 生化机理 | Formoterol Fumarate is shown to be a potent β-AR adrenoceptor agonist, with a fast onset of effect on the isolated human bronchus model. This compound demonstrates a 330-fold selectivity for β2 over β1 receptors. Formoterol Fumarate has been reported to be 150-200 times more potent than isoprenaline. This agent has also been noted to reduce the loss of muscle mass in murine models. |
| 别名 | 富马酸福莫特罗; N-[2-羟基-5[(RS)-1-羟基-2-[(RS)-2-(4-甲氧基苯基)-1-甲基乙基胺]乙基]苯基]甲酰胺半富马酸;Foradil;N-[2-Hydroxy-5-[[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (E)-2-butenedioate |
