产品描述
| 熔点 | 228-230 °C |
| 敏感性 | 对湿度敏感 |
| 溶解性 | Soluble in water (<1 mg/ml at 25 °C), chloroform, DMSO (117 mg/ml at 25 °C), methanol, and ethanol (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An M3 muscarinic acetylcholine receptor blocker. |
| 产品介绍 | Darifenacin HBr是一种选择性的M3 muscarinic（M3蕈毒碱）受体拮抗剂，pKi为8.9。 |
| 备注 | Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9. |
| 生化机理 | Darifenacin hydrobromide is an antispasmodic muscarinic antagonist, selective for blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. Darifenacin hydrobromide has 9 and 12-fold greater affinity for M3 compared to M1 and M5, respectively, and 59-fold greater affinity for M3 compared to both M2 and M4. Darifenacin is used clinically to treat urinary incontinence and overactive bladder syndrome. |
| 别名 | 氢溴酸达非那新; {1-[2-(2,3-二氢苯并呋喃-5-基)乙基]-3-吡咯烷基}-2,2-二苯基乙酰胺氢溴酸盐;UK 88525-04;Enablex;Darifenacin hydrobromide;(3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide hydrobromide ;UK 88525-04;{1-[2-(2,3-Dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidnyl}-2,2-diphenylacetamide hydrobromide;Diphenyl-acetamide hydrobromide |
