产品描述
| 熔点 | 130-135° |
| 敏感性 | 对光敏感 |
| 溶解性 | Solubility: Soluble in water |
| 应用 |
An antagonist of the histamine H1-receptor.(±)-Chlorpheniramine maleate salt has been used: · as H1 receptor antagonist to determine the receptor function · to block the effect of compound 48/80 on plasma IGF-I · as a standard for fast sensing and determination by sequential injector coupled with potentiometer |
| 产品介绍 | Chlorpheniramine Maleate是一种组胺H1受体拮抗剂，IC50为12 nM。 |
| 备注 | Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM. |
| 生化机理 | Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate. |
| 别名 | 马来酸氯苯那敏;扑尔敏;氯屈米通;马来那敏;Chlorphenamine maleate; Piriton;Puermin; Chlortrimeton |
