产品描述
| 熔点 | 245°C |
| 旋光率 | +35.0 to +41.0 deg(C=2,MeOH) |
| 溶解性 | Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), water (3 mg/ml), 0.1N HCl (0.51 mg/ml), isopropyl alcohol (4.3 mg/ml), chloroform (110 mg/ml), and dimethylsulfoxide (147 mg/ml). |
| 存贮条件 | 储存温度2-8°C |
| 应用 | 在长期准备好的绵羊胎儿中研究了盐酸舍曲林暴露的影响。将其用于糖皮质激素功能测定，研究抗抑郁药对人体糖皮质激素受体功能的影响。 |
| 产品介绍 | Sertraline HCl是一种5-HT抑制剂， Ki值为13 nM. |
| 备注 | Sertraline HCl is a 5-HT antagonist with Ki of 13 nM. |
| 生化机理 | Sertraline HCl is a selective and potent inhibitor of ST (serotonin transporter), increasing availability of serotonin in the brain. Sertraline displays antiproliferative activity on human colorectal carcinoma cells. |
| 别名 | (1S,4S)-4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-L-萘胺盐酸盐;(1S,4S)-1-(3,4-二氯苯基)-1,2,3,4-四氢-4-(甲氨基)萘盐酸盐;舍曲林盐酸盐;[(1S)-顺式]-4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺盐酸盐;盐酸舍曲林;(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride;Zoloft; Lustral |
