产品描述
| 熔点 | 198-200 °C |
| 敏感性 | 对热敏感,对空气敏感 |
| 溶解性 | Soluble in water (Partly miscible), DMSO (25 mg/mL warm), ethanol (5 mg/mL warm), chloroform, ethyl acetate, DMF (~20 mg/mL), and 1:1 solution of DMSO:PBS(pH 7.2) (~0.5 mg/mL). |
| 存贮条件 | 储存温度 2-8°C ,充氩保存 |
| 应用 | An inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2. |
| 产品介绍 | Piroxicam 是一种非选择性COX抑制剂，IC50为6 mM。 |
| 备注 | Piroxicam (Feldene) is a non-selective COX inhibitor with an IC50 of 6 mM. |
| 生化机理 | Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Studies show that Piroxicam blocks release of platelet ADP, and inhibits Cox-1 (human prostaglandin H synthase isozyme-1, hPGHS-1) more potently than Cox-2 (hPGHS-2). Piroxicam is also a non-steroidal compound with anti-inflammatory properties. |
| 别名 | 2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物;吡啶苯噻酰胺 ;吡氧噻嗪;炎痛喜康;吡罗昔康;Piroxicamum;Larapam;Feldene;4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide; 4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2H-1,2-benzothiazine 1,1-Dioxide |
