产品描述
| 熔点 | 211-213 oC |
| 溶解性 | DMSO: ≥20 mg/mL, clear, light yellow H2O: insoluble |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | AR-A014418是GSK3β选择性抑制剂，IC50为104 nM，对其它26种激酶无明显抑制性。 |
| 生化机理 | Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC50 = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3. |
| 别名 | GSK-3beta 抑制剂 VIII；N-(4-甲氧基苄基)-N'-(5-硝基-1,3-噻唑-2-基)脲;AR-AO 14418;AR 0133418;AR 014418;GSK 3β inhibitor；N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea |
