产品描述
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 应用 | A potent and selective TORC1/2 inhibitor |
| 产品介绍 | INK 128是高活性mTOR抑制剂，IC50为1 nM，比对其它I型PI3K亚型的抑制性高200倍。 |
| 生化机理 | INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases [1]. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2. Furthermore, INK 128 also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors |
| 别名 | INK-128;MLN0128； 3-(2-氨基-5-苯并恶唑基)-1-(1-甲基乙基)-1H-吡唑并(3,4-d)嘧啶-4-胺;;Sapanisertib; MLN0128； 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1h-pyrazolo(3,4-d)pyrimidin-4-amine；3-(2-aminobenzo[d]oxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
