产品描述
| 折光率 | 1.76 |
| 溶解性 |
|
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.4400 |
| 应用 | A potent inhibitor of PI 3-kinase and FRAP (mTOR) |
| 产品介绍 | GSK1059615是可逆的PI3Kα/β/δ/γ和mTOR双重抑制剂，IC50为0.4 nM/0.6 nM/2 nM/5 nM和12 nM。 |
| 生化机理 | GSK 1059615, a pyridinylquinoline derivative, is a novel, ATP-competitive, and reversible class I PI 3-kinase inhibitor. GSK 1059615 inhibits PI 3-kinase signaling and induces G1 arrest and apoptosis, especially in breast tumor cells. GSK 1059615 inhibits PI 3-kinase α (IC50 of 2 nM, Ki of 0.42 nM), β (Ki of 0.6 nM), γ (Ki of 0.47 nM) and δ (Ki of 1.7 nM). GSK 1059615 is also an inhibitor of mTOR (FRAP) (IC50 of 0.4-12 nM). |
| 别名 | GSK 1059615; GSK-1059615; (5Z)-5-((4-(4-吡啶基)-6-喹啉基)亚甲基)-2,4-噻唑烷二酮;;GSK 1059615;GSK-1059615;(5z)-5-((4-(4-pyridinyl)-6-quinolinyl)methylene)-2,4-thiazolidinedione |
