产品描述
| 溶解性 | Soluble in DMSO (10 mg/ml), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C., Soluble in DMSO (10 mg/ml), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C. |
| 存贮条件 | 储存温度-20°C |
| 应用 | A compound that acts as potent, ATP-competitive & highly selective GSK-3 inhibitor |
| 产品介绍 | CHIR-99021 (CT99021)是GSK-3α和β抑制剂，IC50分别为10 nM和6.7 nM，比对CDC2，ERK2及其他激酶的抑制性强500倍。 |
| 生化机理 | GSK-3 Inhibitor XVI is a cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). CHIR99021 exhibits little to no activity toward 46 other enzymes (IC50 >8.8 μM against 20 kinases and Ki ≥5 μM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 μM). |
| 别名 | CT99021;CHIR99021;CHIR 99021;CT-99021;6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈CT99021;CHIR99021;CHIR 99021;CT-99021;6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile |
