XL147

XL147

产品参数

货号 规格 操作
X129499-50mg 咨询
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服务地域:全国

属性:产地:上海; 品牌:阿拉丁 ;货期:现货

上海阿拉丁生化科技股份有限公司

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产品描述产品描述
  • 分子式 C21H16N6O2S2
  • 分子量448.52

属性

溶解性 DMSO 3 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件 储存温度-20°C

描述

应用 An ATP-competetive class I PI3K inhibitor.
产品介绍 XL147是一种选择性的,可逆的I型PI3K抑制剂,对PI3Kα/δ/γ有抑制作用,IC50分别为39 nM/36 nM/23 nM,对PI3Kβ作用效果稍弱。
备注 XL147 is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM, less potent to PI3Kβ. Phase 1/2.
生化机理 XL-147 derivative 2 is an ATP-competitive inhibitor of class I PI3K isoforms. XL-147 derivative 2 abrogates Akt and S6 phosphorylation in HER2+ cells and also induces the expression and phosphorylation of HER3 and other RTKs. Treatment with the anti-HER2 agents trastuzumab or lapatinib sensitizes HER2+ breast cancer cells to XL-147 derivative 2 in vitro. Treatment with XL-147 derivative 2 inhibits the monolayer growth of all tested cell lines, including BT474, HCC1937 et al. in a dose-dependent manner. XL-147 derivative 2 induces cell death at a concentration of 20 μM by inducing a reduction in cyclin D1 and pRB and increasing in levels of the CDK inhibitor p27KIPI. In HER2-overexpressing cells, inhibition of PI3K is followed by up-regulation of expression and phosphorylation of multiple receptor tyrosine kinases, including HER3.
别名 XL 147; N-[3-(2,1,3-苯并噻二唑-5-氨基)-2-喹喔啉基]-4-甲基苯磺酰胺;PI3K inhibitor X;N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide;XL-147 derivative 2
AI问答 配套的仪器设备? X
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