产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | A small molecule that induces TRAIL in a p53-independent manner |
| 产品介绍 | TIC10(ONC201 isomer)是口服活性的稳定化合物，能抑制Akt和ERK，能透过血脑屏障，可诱导TRAIL。 |
| 备注 | TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. |
| 生化机理 | TIC10 (TRAIL-inducing compound 10) is an orally active, stable and potent small molecule that has been shown to transcriptionally induce TRAIL and TRAIL-mediated cell death in a p53-independent manner. TIC10 also activates the gene Foxo3a by dually inactivating Akt and ERK. TIC10 crosses the blood-brain barrier and is expected to be useful as an antitumor therapeutic agent. |
| 别名 | ONC201, NSC 350625;2,6,7,8,9,10-六氢-10-[(2-甲基苯基)甲基]-7-(苯基甲基)咪唑并[1,2-a]吡啶并[4,3-d]嘧啶-5(3H)-酮;TRAIL-inducing Compound 10;TIC10 isomer; ONC201 isomer;2,6,7,8,9,10-Hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one |
