产品描述
| 熔点 | 177-180 °C |
| 溶解性 | Soluble in DMSO (11 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 0.5% methylcellulose/0.2% Tween 80 (30 mg/ml at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A PDK1 inhibitor and inducer of caspase and p53-independent apoptosis. |
| 产品介绍 | OSU-03012 (AR-12)是一种有效的重组PDK-1抑制剂，IC50为5 μM，比OSU-02067作用效果高2倍。 |
| 备注 | OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
| 生化机理 | OSU 03012 is a potent inhibitor of PDK1 (IC50 = 5 μM). OSU 03012 causes a dose-dependent induction of cell death regardless of the presence or absence of mutated p53. Studies have shown that upon treatment of cells with OSU 03012 there is an accumulation of reactive oxygen species (ROS) in the cell, which may contribute to cell death through oxidative damage. Exposure to ionizing radiation following treatment with OSU 03012 causes an increase in cell death, which is also caspase-independent. |
| 别名 | 2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺;N/AAR-12; OSU03012; OSU 03012;2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide |
