溶解性 |
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存贮条件 | 储存温度-20°C |
应用 | A PI 3-kinase family inhibitor |
产品介绍 | BKM120 (NVP-BKM120, Buparlisib)是一种选择性PI3K抑制,作用于p110α/β/δ/γ时,IC50分别为52 nM/166 nM/116 nM/262 nM,对VPS34, mTOR, DNAPK作用效果降低,对PI4Kβ几乎没有抑制活性。Phase 2。 |
备注 | BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Phase 1/2. |
生化机理 |
NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3 Kinase Inhibitor for treating Cancer.BKM120 is a potent and cell permeable inhibitor of the PI 3-kinase family. Specifically inhibits p110α, p110β, p110γ and p110δ with IC50 of 52 nM, 166 nM, 262 nM and 116 nM, respectively. |
别名 | NVP-BKM120, Buparlisib;NVP-BKM-120; 5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺;NVP-BKM120; Buparlisib; 5-(2,6-di-4-Morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine |