产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | A PI3K inhibitor and antiplatelet agent. |
| 产品介绍 | AZD6482是一种PI3Kβ抑制剂，IC50为10 nM，作用于PI3Kβ比作用于PI3Kδ， PI3Kα和PI3Kγ选择性分别高8，87和109倍。 |
| 备注 | AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. Phase 1. |
| 生化机理 | AZD6482 inhibits PI3Kα, β, γ, and δ, with IC50 of 21 nM to 1.4 μM. AZD6482 is an antiplatelet agent; it blocks platelet activation adhesion/aggregation and promotes platelet disaggregation in an assay of washed platelet aggregation (WPA), with an IC50 value of 6 nM. Furthermore, by targeting PI3Kβ, AZD6482 specifically inhibits thrombosis without interfering with normal haemostasis. |
| 别名 | AZD 6482; 2-[[(1R)-1-[7-甲基-2-(4-吗啉基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-9-基]乙基]氨基]苯甲酸;2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid;(R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid |
