产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 产品介绍 | AS-605240是PI3Kγ选择性抑制剂，IC50为8 nM。比对PI3Kδ，PI3Kβ和PI3Kα的抑制性强30倍和7.5倍。 |
| 备注 | AS-605240 selectively inhibits PI3Kγ with IC50 of 8 nM, over 30-fold and 7.5-fold more selective for PI3Kγ than PI3Kδ/β and PI3Kα, respectively. |
| 生化机理 |
AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. AS-605240 suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive. |
| 别名 | AS605240; AS 605240; 5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮;;AS605240; AS 605240；5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione; pi 3-k|? inhibitor |
