产品描述
| 溶解性 | 25°C: DMSO2mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A novel inhibitor of Met (IC50 = 0.13 nM) |
| 产品介绍 | INCB28060是高活性c-MET口服活性抑制剂，IC50为0.13 nM。 |
| 备注 | INCB28060 is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM, inactive against RONβ, as well as EGFR and HER-3. Phase 1. |
| 生化机理 | INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration. |
| 别名 | INCB-28060; INC-280；2-氟-N-甲基-4-(7-((喹啉-6-基)甲基)咪唑并(1,2-b)-(1,2,4)三嗪-2-基)苯甲酰胺;;Capmatinib; INCB-28060; INC-280;2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2- yl)benzamide |
