产品描述
| 溶解性 | Soluble in DMSO (25 mg/mL warming), ethanol (25 mg/mL warming), methanol, and chloroform. Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
| 应用 |
A Met inhibitor effective against various cell lines Crizotinib has been used: · to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis · to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells · to restore sensitivity to erlotinib |
| 产品介绍 | PF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM. |
| 生化机理 | 克唑替尼（PF-02341066）是受体酪氨酸激酶。 |
| 别名 | 克里唑替尼;3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺;克唑替尼, （R）-3-[1-（2,6-二氯-3-氟 - 苯基）-乙氧基]-5-（1-哌啶-4-基-1H-吡唑-4-基）-吡啶-2-基胺 ;Xalkori;(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine;PF 2341066, PF-02341066, PF02341066 |
