产品描述
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | CGI-1746是Btk抑制剂。 |
| 生化机理 |
CGI-1746 is a small-molecule Bruton's tyrosine kinase (Btk) inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. CGI-1746 has exquisite selectivity for Btk and inhibits both auto- and transphosphorylation steps necessary for enzyme activation. CGI-1746 is useful for heumatoid Arthritis |
| 别名 | CGI1746;CGI 1746； N-(3-(4,5-二氢-4-甲基-6-((4-(4-吗啉基羰基)苯基)氨基)-5-氧代-2-吡嗪基)-2-甲基苯基)-4-(叔丁基)苯甲酰胺;;CGI1746; CGI 1746；n-(3-(4,5-dihydro-4-methyl-6-((4-(4-morpholinylcarbonyl)phenyl)amino)-5-oxo-2-pyrazinyl)-2-methylphenyl)-4-(tert-butyl)benzamide |
