产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | A porcupine homolog - Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase |
| 产品介绍 | Wnt-C59(C59)是高活性Wnt信号转导拮抗剂，IC50为74 pM。 |
| 生化机理 | C59 inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by inhibition of Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity . Wnt-C59 was used at 0.1-0.2 μM to completely block Wnt protein secretion. When used at 0.5 μM, it can be used functionally replace the Dkk protein in many assay conditions. |
| 别名 | Wnt C59;C59; 4-(2-甲基-4-吡啶基)-N-(4-(3-吡啶基)苯基)苯乙酰胺;;Wnt C59;C59; 4-(2-methyl-4-pyridinyl)-n-(4-(3-pyridinyl)phenyl)benzeneacetamide |
