溶解性 |
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存贮条件 | 储存温度-20°C |
应用 | An inhibitor of Activin receptor-like kinase 5 |
产品介绍 | SB505124是一种选择性TGFβR抑制剂,作用于ALK4和ALK5,无细胞试验中IC50分别为129 nM和47 nM,也抑制ALK7,但不抑制ALK1,2,3或6。 |
备注 | SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. |
生化机理 | SB-505124 is an inhibitor of activin receptor-like kinase (ALK-5). SB-505124 is demonstrated to suppress the action of transforming growth factor-B (TGF-B) both in vitro and in vivo. |
别名 | 2-[4-(1,3-苯并二恶茂-5-基)-2-(叔丁基)-1H-咪唑-5-基]-6-甲基吡啶;SB505124;SB 505124;SB505124;2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine |