产品描述
| 溶解性 | Soluble in water (50 mg/ml). |
| 存贮条件 | 2-8℃保存。 |
| 密度 | 0.8730 |
| 应用 | An antibiotic for cell culture. |
| 产品介绍 | Streptomycin sulfate is an aminocyclitol glycoside antibiotic which interferes with protein synthesis in prokaryotes. This antibiotic is effective against both gram-positive and gram-negative bacteria and is frequently used in cell culture media. Streptomycin inhibits protein synthesis by binding to the 30S ribosomal subunit at the S12 protein thereby inducing a misreading of the genetic code, inhibiting the initiation of translation of DNA which then results in death for a susceptible bacterium. |
| 生化机理 | Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. |
| 别名 | 硫酸链霉素;链霉素硫酸盐，链霉素;Streptomycin sulphate streptomycin, sulfate |
