产品描述
| 熔点 | 108-111°C |
| 溶解性 | Soluble in water, 100% ethanol (25 mg/mL), ethyl acetate (50 mg/mL), amyl acetate, DMSO (10 mg/mL), acetone, ethyl ether (sparingly), benzene (sparingly), and dichloromethane (10 mg/mL) |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.5200 |
| 应用 | An inhibitor of protein prenylation |
| 产品介绍 | Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies suggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins. |
| 别名 | 4-羟基-4H-呋[3,2-c]吡喃-2(6H)-酮;4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one |
