产品描述
| 旋光率 | -80 ° (C=2, H2O) |
| 敏感性 | 对光、热敏感 |
| 溶解性 | Soluble in water at 50mg/ml/n |
| 存贮条件 | 2-8℃密封避光保存。 |
| 应用 |
多粘菌素B为抗革兰阴性杆菌多肽类抗生素, 可以改变膜结构使小分子物质泄漏而抑制革兰氏阴性菌的生长。对大肠杆菌具有杀菌作用。结合到细菌脂多糖类的脂质A部分。在外皮细胞膜诱发小孔。 作用模式: 结合并干涉细胞质膜的渗透性。 抗菌谱: 革兰式阴性细菌。 |
| 产品介绍 | 易溶于40％的乙醇水溶液中，溶于水。在醚、酮、酯、烃等有机溶剂中几乎不溶解。 Chemical structure: peptide |
| 生化机理 | Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides?, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. |
| 别名 | 硫酸多粘菌素B ;多粘菌素B硫酸盐 ;Polymyxin B sulfate salt |
