产品描述
| 熔点 | 145℃ - 146℃ |
| 敏感性 | 对湿度敏感 |
| 溶解性 | Soluble in chloroform (9.80 - 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water. |
| 存贮条件 | 储存温度-20°C，充氩储存 |
| 应用 |
Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes. |
| 产品介绍 | Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request |
| 生化机理 | Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation |
| 别名 | 铵离子载体;Ammonium Ionophore; Werramycin-A; Polynactin |
