产品描述
| 溶解性 | Soluble in 1N HCl (20 mg/ml, yielding a clear, colorless to faint yellow solution), and DMSO (75 mM). Insoluble in water. |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A glycosidase inhibitor and antiinflammatory agent. |
| 生化机理 | Castanospermine, originally derived from Castanosperum australe has been shown to be a potent inhibitor of almond emulsion β-glucosidase, and also to inhibit fungal β-xylosidase. Other studies show castanospermine to have the capacity to make viral glycopeptides more susceptible to enzyme treatment. Additionally, castanospermine may have the potential ability to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. |
| 别名 | (1S,6S,7R,8R,8aR)-1,6,7,8-四羟基八氢吲哚里西定;(1S,6S,7R,8R,8aR)-八氢-1,6,7,8-吲嗪四醇; 1,6,7,8-四羟基八氢吲嗪;(1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-八氢吲嗪-1,6,7,8-四醇;栗树精胺;(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine; (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol; 1,6,7,8-Tetrahydroxyoctahydroindolizine; 6,7-Diepicastanospermine |
