产品描述
| 熔点 | 98 °C |
| 敏感性 | 对热敏感 |
| 溶解性 | DMSO: 20 mg/mL;insoluble in water & Ethanol |
| 存贮条件 | 储存温度：-20°C |
| 密度 | 1.3500 |
| 应用 |
A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores. · 降低剪切后半胱氨酸蛋白酶-3升高水平 · 阻止细胞死亡，抑制ROS（活性氧化簇）产物，抑制半胱氨酸蛋白酶-8活性。 · 排除细胞内Ca2+ ([Ca2+]i) 浓度变化对癫痫诱导影响 · 消除6-羟多巴胺(6-OHDA)诱导的[Ca2+]i增量水平 |
| 产品介绍 | BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C. Has also been shown to inhibit thapsigargin-induced apoptosis in rat thymocytes. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. BAPTA-AM抑制自由基介导的毒性，增强非神经细胞中细胞凋亡，保护神经细胞免受缺血性损伤。它调节离子通道，阻止神经Ca2+-激活K+通道电流。BAPTA-AM维持细胞内Ca2+动态平衡。 |
| 生化机理 | 细胞内Ca2+储存选择性螯合剂。 |
| 别名 | 1,2-双(2-氨基苯氧基)乙烷-N,N,N`,N`-四乙酸四乙酸甲酯;胞内钙荧光探针BAPTA-AM;1,2-双(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸四(乙酸基甲基)酯；1,2-双(2-氨基苯氧基)-乙烷-N,N,N,N′-四乙酸 ;1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester);Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate;1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid Tetrakis(acetoxymethyl) Ester |
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