产品描述
| 熔点 | 252-253 °C |
| 敏感性 | 对光和湿度敏感 |
| 溶解性 | Soluble in DMSO (20 mg/ml), ethanol, chloroform (1 mg/ml), and dichloromethane (20 mg/ml). |
| 存贮条件 | 储存温度-20℃ |
| 应用 | A fluorescent DNA dye for apoptosis and flow cytomtery studies. |
| 产品介绍 | 7-Aminoactinomycin D ，an analog of the antibiotic actinomycin D ，is a fluorescent DNA dye which is useful for quantifying apoptosis. 7-AAD has also been used in studies on cellular necrosis, chromosome analysis and in cell cycle studies. As a fluorescent DNA dye, 7-AAD is able to intercalate DNA via binding to the GC regions. When used in flow cytometery, 7-AAD can be used to discriminate between live cells as well as early and late apoptosis. Additionally, 7-AAD can also be combined with other staining procedures for analysis of intracellular and cell surface antigens enabling multiparametric analysis. When utilizing 7-AAD with flow cytometery, early and late apoptosis can be studied by varying the concentration of 7-AAD. During apoptosis, the cellular plasma membrane is altered progressively, which allows the cell membrane to become permeable to 7-AAD. 7-AAD staining can also be adapted to include staining with other dyes for intracellular and cell surface antigens. 7-Aminoactinomycin D is an inhibitor of DNA Polymerase and RNA Polymerase |
| 别名 | 7-AAD; 7-AminoActinomycin D;7-AAD |
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