溶解性 | Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol. |
应用 |
Minoxidil has been used as test drug: · in dermal papilla spheroid model, to study the effectof hair regeneration · administered orally to experimental rats, in theapproach to identify biomarkers of drug induced vascular injury · administered via oral gavage to nonhuman primate modelin order to study its effect on tilt responses |
生化机理 |
Minoxidil is originally used to treat hypertension,which also induces hypertrichosis. It is considered as a potent drug fortreating androgenetic alopecia. Activates ATP-activated K+ channels;vasodilator; slow or stop hair loss and promote hair regrowth. |
别名 | 6-(1-哌啶基)-2,4-嘧啶二胺 3-氧化物, 6-(1-哌啶基)嘧啶-2,4-二胺 3-氧化物;米诺地尔;2,6-二氨基-4-哌啶并嘧啶1-氧化物;;6-(1-Piperidinyl)-2,4-pyrimidinediamine;3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide;2,6-Diamino-4-piperidinopyrimidine 1-Oxide |