产品描述
| 沸点 | ~689.8° C at 760 mmHg |
| 熔点 | 294.92° C |
| 折光率 | 1.60 |
| 溶解性 | DMSO: >10 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.2000 |
| 应用 | A selective BCRP multidrug transporter inhibitor |
| 产品介绍 | Ko 143是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，EC90为26 nM，比对 P-gp和MRP-1转运通道的抑制性高200倍以上。 |
| 生化机理 | Ko 143 is a potent and selective ABCG2 (breast cancer resistance protein multidrug transporter, BCRP) inhibitor (EC90 = 26 nM). It displays > 200-fold selectivity over P-gp and MRP-1 transporters. Ko 143 also increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. |
| 别名 | Ko-143; Ko143;(3S,6S,12aS)-1,2,3,4,6,7,12,12a-八氢-9-甲氧基-6-(2-甲基丙基)-1,4-二氧代吡嗪并[1',2':1,6]吡啶并[3,4-b]吲哚-3-丙酸叔丁酯;Ko-143; Ko143;(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-( 2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4- b]indole-3-propanoic acid 1,1-dimethylethyl ester；Ko143 hydrate; Ko-143 hydrate |
