溶解性 | Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C)., |
存贮条件 | 储存温度-20°C |
应用 | A sequiterpene lactone that inhibits telomerase |
产品介绍 | Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway |
生化机理 |
Description: |
别名 | ;(3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one |